Godet J, Blanchet J P, Nigon V
Ann Immunol (Paris). 1976 Nov-Dec;127(6):865-72.
Between the 18th and 20th day of incubation, the proportion of haemoglobin F (Hb F) synthesis decreases in the embryo bone marrow from the value found in the yolk sac (10% of the total haemoglobin synthesis) to the value found in the bone marrow of young chicks (2%). A similar drop in Hb F synthesis is observed with a delay of 48 hours in the blood. Two membrane antigens each specific of either embryo or adult erythrocytes have been detected. The study by immunofluorescence of their cellular distribution shows that 3 erythrocyte populations are successively produced: a population E bearing the embryonic antigen only, a population EA bearing both antigens and a population A bearing the adult antigen only. The presence of a relatively high proportion of Hb F in population E is strongly suggested by the similar kinetics of Hb F and E cells disappearance within the first posthatching month.
在孵化的第18至20天之间，胚胎骨髓中血红蛋白F（Hb F）的合成比例从卵黄囊中发现的值（占总血红蛋白合成的10%）降至幼雏骨髓中发现的值（2%）。在血液中观察到Hb F合成有类似下降，但延迟48小时。已检测到两种分别对胚胎或成年红细胞特异的膜抗原。对其细胞分布进行免疫荧光研究表明，依次产生了3种红细胞群体：仅带有胚胎抗原的E群体、带有两种抗原的EA群体和仅带有成年抗原的A群体。孵化后第一个月内Hb F和E细胞消失的相似动力学强烈提示E群体中存在相对较高比例的Hb F。
