Sillin L F, Schulte W J, Woods J H, Cowles V E, Condon R E, Bass P
Am J Surg. 1979 Jan;137(1):99-105. doi: 10.1016/0002-9610(79)90018-7.
Serosal bipolar electrodes to record spike discharges and strain gauge force transducers to record circular muscle contractions were placed in pairs on the terminal ileum, cecum, right colon at the ileocecal valve, ascending colon, and proximal transverse colon of sixteen primates. After an overnight fast, electromotor responses to continued fasting or to ingestion of a meal (randomized order) were recorded in awake animals. Feeding led to increased spike discharges and increased frequency of muscle contractions at all sites. The onset of these responses usually was within 6 minutes after feeding; the responses increased progressively during 30 to 45 minutes and then remained more or less at a constant plateau of increased activity. Atropine completely blocked the postcibal responses of ileum and proximal colon for up to 30 minutes. Transit time data of labeled meals excluded direct stimulation by a food bolus as the mechanism of the observed postcibal colonic response. The pattern of response was consistent with humoral mediation.
将用于记录尖峰放电的浆膜双极电极和用于记录环形肌收缩的应变片力传感器成对放置在16只灵长类动物的回肠末端、盲肠、回盲瓣处的右结肠、升结肠和近端横结肠上。在禁食过夜后，记录清醒动物对持续禁食或进食（随机顺序）的电运动反应。进食导致所有部位的尖峰放电增加和肌肉收缩频率增加。这些反应通常在进食后6分钟内开始；在30至45分钟内反应逐渐增强，然后或多或少保持在活动增加的恒定平台期。阿托品可完全阻断回肠和近端结肠的餐后反应长达30分钟。标记餐的转运时间数据排除了食物团块直接刺激作为观察到的餐后结肠反应机制的可能性。反应模式与体液介导一致。
