Meshkinpour H, Harmon D, Thompson R, Yu J
Dig Dis Sci. 1987 Jul;32(7):743-6. doi: 10.1007/BF01296141.
The colon motor response to a meal consisting of 100 mM of sodium oleate was assessed before and after neodecortication in male Sprague-Dawley rats. Recording probes were anchored surgically in the ascending and descending colon. Pressure changes were recorded on a dynograph using a low-compliance perfusion system. A motility index took into account the amplitude, duration, and frequency of contractions. Neodecortication increased the motility index of the distal colon in the fasting state. However, removal of the cerebral cortex did not affect significantly the colon motor response to a meal. Meal stimulation increased the motility index before and after neodecortication. These findings suggest that resting colonic motor activity is increased after neodecortication, probably through the loss of an inhibitory influence of the central nervous system; and the cerebral cortex is not required for the colon response to a meal in the rat.
在雄性斯普拉格-道利大鼠进行去新皮质手术前后，评估了结肠对含100 mM油酸钠餐食的运动反应。记录探头通过手术固定在升结肠和降结肠。使用低顺应性灌注系统在记录仪上记录压力变化。运动指数考虑了收缩的幅度、持续时间和频率。去新皮质手术增加了禁食状态下远端结肠的运动指数。然而，去除大脑皮质对结肠对餐食的运动反应没有显著影响。餐食刺激在去新皮质手术前后均增加了运动指数。这些发现表明，去新皮质手术后静息结肠运动活性增加，可能是由于中枢神经系统抑制性影响的丧失；并且大鼠结肠对餐食的反应不需要大脑皮质。
