Strom J A, Condon R E, Schulte W J, Cowles V, Go V L
Am J Surg. 1982 Jan;143(1):155-9. doi: 10.1016/0002-9610(82)90147-7.
Serosal bipolar electrodes and strain gauge force transducers were placed on the right and left colon in subhuman primates to record spike discharges and circular muscular contractions. The effect of glucagon on colonic motor and electrical activity were studied before and after meals. Serum concentration of gastric inhibitory polypeptide was measured simultaneously 15 minutes before and 45 minutes after eating. Serum levels of gastric inhibitory polypeptide increased in response to eating; pre- and postcibal concentrations were not altered by glucagon. The gastrocolic response of the colon to eating was demonstrated. Glucagon inhibited the intrinsic activity of the entire colon before meals and partly inhibited the right colon after meals. Postcibal left colon activity was not inhibited by glucagon. This indicates that a distinct mechanism accounts for the left colonic postcibal increase in contractile and electrical spike activity. A neural or humoral mechanism is implicated but is not specifically identified.
在非人灵长类动物的左右结肠放置浆膜双极电极和应变片力传感器，以记录锋电位发放和环形肌收缩。研究了进食前后胰高血糖素对结肠运动和电活动的影响。同时在进食前15分钟和进食后45分钟测量血清胃抑制性多肽浓度。进食后血清胃抑制性多肽水平升高；胰高血糖素未改变进食前后的浓度。证实了结肠对进食的胃结肠反射。胰高血糖素在进食前抑制整个结肠的内在活性，进食后部分抑制右半结肠。进食后胰高血糖素未抑制左半结肠的活性。这表明一种独特的机制导致进食后左半结肠收缩和电锋电位活动增加。涉及一种神经或体液机制，但未具体确定。
