Yanaura S, Abe Y, Funada K, Hosokawa T
Nihon Yakurigaku Zasshi. 1976 Sep;72(6):701-8.
In the present study, effects of psychotropic drugs were analyzed by observing avoidance and escape behavior or rabbits under hypothalamic electrical stimulation. In avoidance behavior, chlorpromazine (CPZ) and diazepam (DZP) depressed avoidance response and extended avoidance response latency and head movement latency. Autonomic behavior such as opening of palpebral fissure and pupil size were also delayed. The locus of movement and count of head movement were depressed by the administration of each drug. On the other hand, unlike CPZ, DZP extended escape response latency. On escape behavior, effects of CPZ and DZP were apparently different. Unlike CPZ, DZP induced avoidance behavior and increased locus of movement. With methamphetamine, no avoidance behavior was observed, but under conditional stimulation, the behavior and the escape response latency were decreased. Chlordiazepoxide induced avoidance behavior.
在本研究中，通过观察下丘脑电刺激下兔子的回避和逃避行为来分析精神药物的作用。在回避行为中，氯丙嗪（CPZ）和地西泮（DZP）抑制回避反应，延长回避反应潜伏期和头部运动潜伏期。诸如睑裂张开和瞳孔大小等自主行为也被延迟。每种药物的给药均使运动轨迹和头部运动次数减少。另一方面，与CPZ不同，DZP延长逃避反应潜伏期。在逃避行为方面，CPZ和DZP的作用明显不同。与CPZ不同，DZP诱发回避行为并增加运动轨迹。使用甲基苯丙胺时，未观察到回避行为，但在条件刺激下，行为和逃避反应潜伏期缩短。氯氮卓诱发回避行为。
