来自海洋海绵Pachastrissa sp.的抗真菌代谢产物：新型苯酰胺和苯并唑衍生物。

Antifungal metabolites from the marine sponge Pachastrissa sp.: new bengamide and bengazole derivatives.

作者信息

Fernández R, Dherbomez M, Letourneux Y, Nabil M, Verbist J F, Biard J F

机构信息

Laboratoire SESNAB, Pôle Science, Université de La Rochelle, 17042 La Rochelle Cedex 1, France.

出版信息

J Nat Prod. 1999 May;62(5):678-80. doi: 10.1021/np980330l.

DOI:10.1021/np980330l

PMID:10346943

Abstract

This paper reports the studies of components of an undescribed sponge in the genus Pachastrissa sp., collected along the Djibouti coast. The extract showed activity against Candida albicans. Six new bengazoles (1-6) and a new bengamide, named bengamide L (16), in addition to the known bengazoles (7-11), bengamides A (12), B (13), E (14), and F (15), and a lactone (17) are described in this paper. All structures were determined on the basis of spectroscopic studies.

摘要

本文报道了对采自吉布提海岸的一种未描述过的帕氏海绵属（Pachastrissa sp.）海绵成分的研究。提取物显示出对白色念珠菌的活性。本文描述了六种新的苯并唑（1 - 6）和一种新的苯并酰胺，命名为苯并酰胺L（16），此外还有已知的苯并唑（7 - 11）、苯并酰胺A（12）、B（13）、E（14）和F（15）以及一种内酯（17）。所有结构均通过光谱研究确定。