来自Jaspis海绵的生物活性天然产物——苯酰胺和苯并唑的化学与生物学特性
Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges.
作者信息
García-Ruiz Cristina, Sarabia Francisco
机构信息
Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Campus de Teatinos s/n., Málaga 29071, Spain.
出版信息
Mar Drugs. 2014 Mar 18;12(3):1580-622. doi: 10.3390/md12031580.
Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures and impressive biological profiles, including antitumor, antibiotic and anthelmintic properties. As a consequence, intense research activity has been devoted to these compounds from both chemical and biological standpoints. This review describes in detail the research into these classes of natural products and the benefits they offer in chemistry and biology.
事实证明，属于Jaspidae科的海绵是生物活性天然产物的丰富来源。其中，苯甲酰胺类和苯并唑类因其前所未有的分子结构和令人瞩目的生物学特性（包括抗肿瘤、抗菌和驱虫特性）而脱颖而出。因此，从化学和生物学角度对这些化合物展开了深入的研究。本综述详细描述了对这些天然产物类别的研究以及它们在化学和生物学方面带来的益处。
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