Qureshi A, Salvá J, Harper M K, Faulkner D J
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.
J Nat Prod. 1998 Dec;61(12):1539-42. doi: 10.1021/np9802724.
Three new cyclic peroxides 5-7 and a new carboxylic acid ester 8 were isolated as minor metabolites from the hexane extract of a Plakinastrella species from the Philippines. The structures of compounds 5-8 were elucidated by interpretation of spectral data and by chemical interconversion, and the absolute stereochemistry of peroxide 6 was determined by application of Mosher's method to a derivative. Although the major compounds in the sponge showed activity against Candida albicans prior to decomposition, the minor metabolites 5-8 are essentially inactive.
从菲律宾一种扁藻属物种的己烷提取物中分离出三种新的环状过氧化物5 - 7和一种新的羧酸酯8作为次要代谢产物。通过光谱数据解释和化学相互转化阐明了化合物5 - 8的结构，并通过将莫舍尔方法应用于衍生物确定了过氧化物6的绝对立体化学。尽管海绵中的主要化合物在分解前对白色念珠菌有活性，但次要代谢产物5 - 8基本无活性。
