一种从萨尔兹曼番荔枝根部提取的新型双四氢呋喃产乙酸天然产物。

A new bistetrahydrofuran acetogenin from the roots of Annona salzmanii.

作者信息

Queiroz E F, Roblot F, Cavé A, Hocquemiller R, Serani L, Laprévote O, Paulo M Q

机构信息

Laboratoire de Pharmacognosie, U.R.A. 1843 CNRS (BIOCIS), Faculté de Pharmacie, 92296 Châtenay-Malabry, France.

出版信息

J Nat Prod. 1999 May;62(5):710-3. doi: 10.1021/np980482g.

DOI:10.1021/np980482g

Abstract

A new bistetrahydrofuran acetogenin, salzmanin (1), was isolated from the MeOH extract of Annona salzmanii, in addition to the known compounds, squamocin, almunequin, bullatalicin, and annonacin. The structure of 1 was elucidated by spectroscopic methods, including LSIMS-MS technique, and confirmed by a chemical transformation. The cytotoxic activity of 1 and squamocin was investigated.

摘要

从萨尔兹曼番荔枝（Annona salzmanii）的甲醇提取物中分离出一种新的双四氢呋喃产乙酸菌素，即萨尔兹曼菌素（1），此外还分离出了已知化合物番荔枝辛、阿尔穆奈昆、布拉他利辛和番荔枝素。通过包括液相二次离子质谱（LSIMS-MS）技术在内的光谱方法阐明了1的结构，并通过化学转化得到证实。研究了1和番荔枝辛的细胞毒性活性。

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