来自马达加斯加干燥森林的 Uvaria sp. 的具有抗增殖作用的二萜。
Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest.
机构信息
Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
出版信息
J Nat Prod. 2012 Mar 23;75(3):479-83. doi: 10.1021/np200697j. Epub 2011 Dec 2.
Abstract
Investigation of the endemic Madagascan plant Uvaria sp. for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new acetogenins. The structures of these two compounds were elucidated on the basis of analysis of their 1D and 2D NMR spectra, circular dichroism, and mass spectrometric data, together with chemical modification. The two acetogenins display weak antiproliferative activity against the A2780 ovarian cancer, the A2058 melanoma, and the H522 lung cancer cell lines.
摘要
对马达加斯加特有植物 Uvaria sp. 的抗增殖活性进行研究，以分离两种新的乙酰氧基酮。这些化合物的结构是基于它们的 1D 和 2D NMR 光谱、圆二色性和质谱数据以及化学修饰的分析来阐明的。这两种乙酰氧基酮对 A2780 卵巢癌细胞、A2058 黑色素瘤细胞和 H522 肺癌细胞系的增殖活性较弱。
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