紫番荔枝二醇和紫番荔枝宁，两种从紫番荔枝种子中分离得到的具有细胞毒性的新型邻位双四氢呋喃类番荔枝内酯。

Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea.

作者信息

Chávez D, Mata R

机构信息

Departamento de Farmacia, Facultad de Química and Unidad de Investigación en Plantas Medicinales, Instituto de Química, Universidad Nacional Autónoma de México, D.F. 04510, Mexico.

出版信息

J Nat Prod. 1998 May;61(5):580-4. doi: 10.1021/np970410+.

DOI:10.1021/np970410+

PMID:9599253

Abstract

Two novel cytotoxic acetogenins, purpurediolin (1) and purpurenin (2), were isolated from the seeds of Annona purpurea. Their structures were elucidated by a combination of chemical and spectral methods including MS and NMR measurements. In addition, six known acetogenins were obtained, namely, bullatacin, squamocin (annonin I), motrilin (squamocin C), annoglaucin, xylomatenin, and annonacin A. Compounds 1 and 2 exhibited potent cytotoxic activity in vitro against six human solid tumor cell lines.

摘要

从番荔枝的种子中分离出两种新型细胞毒性产乙酸菌素，紫红素（1）和紫红素宁（2）。通过包括质谱和核磁共振测量在内的化学和光谱方法相结合来阐明它们的结构。此外，还获得了六种已知的产乙酸菌素，即布拉他辛、鳞霉素（番荔枝素I）、莫替林（鳞霉素C）、番荔枝青素、木苹果宁和番荔枝素A。化合物1和2在体外对六种人类实体瘤细胞系表现出强大的细胞毒性活性。