白千层属物种对桦木酸的糖基化作用。
Glucosidation of betulinic acid by Cunninghamella species.
作者信息
Chatterjee P, Pezzuto J M, Kouzi S A
机构信息
Division of Basic Pharmaceutical Sciences, School of Pharmacy, Northeast Louisiana University, Monroe, Louisiana 71209, USA.
出版信息
J Nat Prod. 1999 May;62(5):761-3. doi: 10.1021/np980432b.
Microbial transformation of the antimelanoma agent betulinic acid (1) was studied. Preparative scale biotransformation with resting-cell suspensions of Cunninghamella species NRRL 5695 resulted in the production of a fungal metabolite of 1, which has been characterized as 28-O-beta-D-glucopyranosyl 3beta-hydroxy-lup-20(29)-en-28-oate (2) based on spectral and enzymic data. The in vitro cytotoxicity assay of metabolite 2 revealed no activity against several human melanoma cell lines.
研究了抗黑色素瘤药物桦木酸（1）的微生物转化。用康宁木霉属NRRL 5695的静止细胞悬浮液进行制备规模的生物转化，产生了1的一种真菌代谢产物，根据光谱和酶学数据，该代谢产物被鉴定为28 - O - β - D - 吡喃葡萄糖基3β - 羟基 - 羽扇 - 20（29） - 烯 - 28 - 酸酯（2）。代谢产物2的体外细胞毒性试验表明，其对几种人黑色素瘤细胞系无活性。
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