从杜恩氏菌中分离得到的五环三萜及其糖苷酶抑制活性。
Pentacyclic Triterpenoids from Dunn and Their -Glycosidase Inhibitory Activities.
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
出版信息
Molecules. 2022 Mar 27;27(7):2161. doi: 10.3390/molecules27072161.
Four new pentacyclic triterpenoids named Sabiadiscolor A-D ( and -) together with eleven known ones were isolated by repeated column chromatography. Their structures were identified and characterized by NMR and MS spectral data as 6 oleanane-type pentacyclic triterpenoids (-), 7 ursane-type ones (-), and 2 lupanane-type ones (-). Except for compound , all other compounds were isolated from Dunn for the first time. Their -glycosidase inhibitory activities were evaluated, which showed that compounds , , , , , and implied remarkable activities with IC values ranging from 0.09 to 0.27 μM, and the preliminary structure-activity relationship was discussed.
四种新的五环三萜化合物命名为 Sabiadiscolor A-D（和-），以及十一种已知的化合物，通过反复的柱层析分离得到。通过 NMR 和 MS 光谱数据鉴定了它们的结构，并确定为 6 种齐墩果烷型五环三萜（-）、7 种乌苏烷型五环三萜（-）和 2 种羽扇豆烷型五环三萜（-）。除了化合物 外，其他所有化合物均首次从 Dunn 中分离得到。评估了它们的-糖苷酶抑制活性，结果表明，化合物 、 、 、 、 和 表现出显著的活性，IC 值范围为 0.09 至 0.27 μM，初步探讨了结构-活性关系。
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