Koç H, Altunhan H, Dilsiz A, Kaymakçi A, Duman S, Oran B, Erkul I
Department of Pediatrics, Faculty of Medicine, University of Selçuk, 42080 Konya, Turkey.
Pediatr Dev Pathol. 1999 Jul-Aug;2(4):333-6. doi: 10.1007/s100249900131.
In this study we investigated the long-term effects of 72-h continuous phototherapy on the reproductive system of newborn rats. The animals' weight, fertilization rates, and number of newborn and histopathological changes in the gonads in a normal group not exposed to phototherapy and in the test animals were compared. At the age of 24 weeks there were no significant differences between the two groups, apart from the histology of the testicles of the male rats who were exposed to the phototherapy. The study group showed a significantly reduced diameter of the seminiferous tubules when compared to the controls (P < 0.001). It can be postulated that phototherapy may cause histological degenerative changes in the structure of the rat's testes, even though there were no changes in fertilization rates. Further studies are necessary to reveal the effects of phototherapy on humans and to determine the effects, if any, on fertility.
在本研究中，我们调查了72小时连续光疗对新生大鼠生殖系统的长期影响。比较了未接受光疗的正常组和实验动物的体重、受精率、新生仔鼠数量以及性腺的组织病理学变化。在24周龄时，两组之间除了接受光疗的雄性大鼠睾丸组织学外，没有显著差异。与对照组相比，研究组的生精小管直径显著减小（P < 0.001）。可以推测，尽管受精率没有变化，但光疗可能会导致大鼠睾丸结构发生组织学退行性变化。有必要进一步研究以揭示光疗对人类的影响，并确定其对生育能力是否有影响（若有影响）。
