Cetinkursun S, Demirbag S, Cincik M, Baykal B, Gunal A
Department of Pediatric Surgery, Gulhane Military Medical Academy, Ankara, Turkey.
Arch Androl. 2006 Jan-Feb;52(1):61-70. doi: 10.1080/01485010500302089.
Phototherapy is the most widespread treatment for lowering bilirubin concentration in neonates. In the routine, phototherapy has some side effects including skin eruption, fluid loss, abdominal distention, mild hemolysis and mild thrombocytopenia. The aim of the study was to investigate the possible mutagenic and gametocidal side effects of 72 h continuous phototherapy on the rat testicle. We observed decreases in spermatogonia numbers per tubule (S/T values), tubular fertilization index (TFI) and sperm sertoli cell index (SSCI), which are the most reliable methods in estimating future fertility potential, due to sensitivity to phototherapy. The differences between study and control groups for S/T, TFI and SSCI values were statistically significant (p = 0.008, p = 0.02 and p = 0.004, respectively). There were significant differences in seminiferous tubule diameters between the control and study groups (p < 0.005), but no significant difference in DNA index values between the control (0.66 +/- 0.12) and study (0.59 +/- 0.05) groups (p > 0.05). As a conclusion, phototherapy seems to have some side effects on the newborn rat testicle. Further studies with larger groups, designed for investigation of the effects of phototherapy on seminiferous tubules, may give more beneficial results.
光疗是降低新生儿胆红素浓度最广泛使用的治疗方法。在常规治疗中，光疗有一些副作用，包括皮疹、体液流失、腹胀、轻度溶血和轻度血小板减少。本研究的目的是调查72小时连续光疗对大鼠睾丸可能产生的致突变和杀配子副作用。我们观察到每小管精原细胞数量（S/T值）、小管受精指数（TFI）和精子支持细胞指数（SSCI）下降，由于对光疗敏感，这些是评估未来生育潜力最可靠的方法。研究组和对照组在S/T、TFI和SSCI值上的差异具有统计学意义（分别为p = 0.008、p = 0.02和p = 0.004）。对照组和研究组之间的生精小管直径存在显著差异（p < 0.005），但对照组（0.66 +/- 0.12）和研究组（0.59 +/- 0.05）之间的DNA指数值无显著差异（p > 0.05）。总之，光疗似乎对新生大鼠睾丸有一些副作用。针对光疗对生精小管影响的更大样本量的进一步研究可能会得出更有益的结果。
