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采用离子对萃取和安培检测的高效液相色谱法测定人血清中的去甲麻黄碱。

High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection.

作者信息

Peinhardt G P

机构信息

Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

出版信息

J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726(1-2):309-12. doi: 10.1016/s0378-4347(99)00068-7.

DOI:10.1016/s0378-4347(99)00068-7
PMID:10348201
Abstract

The method for the quantitation of pholedrine in human serum involves extraction of the sample with benzene utilizing an ion-pairing reagent, bis(2-ethylhexyl)phosphoric acid, and re-extraction into diluted phosphoric acid. Analysis is carried out on a ODS reversed-phase column with heptanesulfonate as the ion-pairing reagent. The procedure allows quantitation at the lower nanogram level and is useful for pharmacokinetic investigations.

摘要

人血清中去甲麻黄碱的定量方法包括

使用离子对试剂双（2-乙基己基）磷酸，用苯萃取样品，然后再萃取到稀磷酸中。分析在以庚烷磺酸盐作为离子对试剂的ODS反相柱上进行。该方法可在低纳克水平进行定量，对药代动力学研究有用。

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