Neubert R, Albrecht G, Taube C, Weiss M, Fürst W
Sektion Pharmazie, Martin-Luther-Universität.
Pharmazie. 1988 Sep;43(9):632-3.
Based on previous in vitro studies it could be shown that ion-pair-formation with the lipophilic hexylsalicylic acid (1) influences the pharmacokinetics of the hydrophilic drug pholedrine (2) which is ionized in all physiological media. After oral combination with 1 an increase of the AUC of 2 could be observed. This finding is due both to the increase of the absorption of 2 and to the decrease of the elimination of 2. After i.v. application the high biotransformation rate of 2 prevents an influence of 1.
基于先前的体外研究可以表明，与亲脂性的己基水杨酸（1）形成离子对会影响亲水性药物去氧肾上腺素（2）的药代动力学，去氧肾上腺素在所有生理介质中均会发生离子化。与1口服联合给药后，可观察到2的AUC增加。这一发现既归因于2吸收的增加，也归因于2消除的减少。静脉注射给药后，2的高生物转化速率可防止1产生影响。
