McIntosh A R, Rajah M N, Lobaugh N J
Rotman Research Institute of Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada.
Science. 1999 May 28;284(5419):1531-3. doi: 10.1126/science.284.5419.1531.
In an associative learning paradigm, human subjects could be divided based on whether they were aware that one tone predicted a visual event and another did not. Only aware subjects acquired a differential behavioral response to the tones. Regional cerebral blood flow in left prefrontal cortex showed learning-related changes only in aware subjects. Left prefrontal cortex also showed changes in functional connectivity with contralateral prefrontal cortex, sensory association cortices, and cerebellum. Several of the interacting areas correlated with aware subjects' behavior. These results suggest cerebral processes underlying awareness are mediated through interactions of large-scale neurocognitive systems.
在一种联想学习范式中，人类受试者可根据他们是否意识到一种音调预示着一个视觉事件而另一种音调则不然来进行划分。只有有意识的受试者获得了对这些音调的差异性行为反应。左侧前额叶皮质的局部脑血流量仅在有意识的受试者中显示出与学习相关的变化。左侧前额叶皮质与对侧前额叶皮质、感觉联合皮质和小脑的功能连接也出现了变化。几个相互作用的区域与有意识受试者的行为相关。这些结果表明，意识背后的大脑过程是通过大规模神经认知系统的相互作用来介导的。
