氟化钠对人红细胞和艾氏腹水癌细胞体外糖酵解的影响。
Effect of sodium fluoride on glycolysis in human erythrocytes and Ehrlich ascites tumour cells in vitro.
作者信息
Gumińska M, Sterkowicz J
出版信息
Acta Biochim Pol. 1976;23(4):285-91.
PMID:1035019
Abstract
In human erythrocytes and Ehrlich ascites tumour cells, NaF inhibites aerobic glucose utilization and lactate formation. The inhibition of glycolysis was accompanied by a decrease in cellular pyruvate and ATP, and by accumulation of 2-hosphoenolpyruvate. These results and direct enzymatic determinations showed that fluoride inhibits, in addition to enolase (phosphopyruvate hydratase, EC 4.2.1.11), also pyruvate kinase.
摘要
在人类红细胞和艾氏腹水瘤细胞中，氟化钠抑制有氧葡萄糖利用和乳酸生成。糖酵解的抑制伴随着细胞内丙酮酸和三磷酸腺苷（ATP）的减少，以及2-磷酸烯醇丙酮酸的积累。这些结果和直接的酶活性测定表明，除了烯醇化酶（磷酸丙酮酸水合酶，EC 4.2.1.11）外，氟化物还抑制丙酮酸激酶。
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