Stephen G W, Cooper L V, Harvey D
Br J Anaesth. 1976 Jul;48(7):635-8. doi: 10.1093/bja/48.7.635.
The newborn rabbit responds to acute anoxia, as a result of breathing nitrogen, with successive periods of dyspnoea, primary apnoea, gasping and terminal apnoea. Pethidine caused an increase in the period of primary apnoea and a decrease in the duration and rate of gasping. When nalorphine was combined with pethidine the period of primary apnoea was still increased although the duration and number of gasps were restored to control values. Naloxone, in contrast, acted as a mild respiratory stimulant, shown as a longer phase of dyspnoea. Also it completely abolished the respiratory depression produced by pethidine. Naloxone may be preferable to nalorphine as a drug to reverse the effects of pethidine immediately after birth.
新生兔因吸入氮气而对急性缺氧产生反应，相继出现呼吸困难期、原发性呼吸暂停、喘息和终末呼吸暂停。哌替啶使原发性呼吸暂停期延长，喘息持续时间和频率降低。当烯丙吗啡与哌替啶合用时，原发性呼吸暂停期仍延长，尽管喘息持续时间和次数恢复到对照值。相比之下，纳洛酮起轻度呼吸兴奋剂的作用，表现为呼吸困难期延长。此外，它完全消除了哌替啶引起的呼吸抑制。作为一种在出生后立即逆转哌替啶作用的药物，纳洛酮可能比烯丙吗啡更可取。
