Smith W D
Br J Anaesth. 1976 Nov;48(11):1039-44. doi: 10.1093/bja/48.11.1039.
The effectiveness of naloxone and nalorphine in antagonizing the effects of fentanyl and droperidol on the hot plate reaction time and the respiratory rate of the mouse has been compared. Naloxone was superior to nalorphine, being a more effective antagonist, and was also free from significant agonist effects. However, neither antagonist was completely effective against the respiratory rate depression produced by combinations of fentanyl and droperidol. It is suggested that the duration of the antagonist effects of naloxone are shorter against respiratory depression than against analgesia.
比较了纳洛酮和烯丙吗啡对芬太尼和氟哌利多所致小鼠热板反应时间及呼吸频率影响的拮抗效果。纳洛酮作为一种更有效的拮抗剂，优于烯丙吗啡，且无明显激动剂作用。然而，两种拮抗剂对芬太尼和氟哌利多联合引起的呼吸频率降低均未完全起效。提示纳洛酮对呼吸抑制的拮抗作用持续时间比对镇痛的拮抗作用持续时间短。
