Kimura S, Suwa J, Ito M, Sato H
Gan. 1976 Oct;67(5):763-5.
Hyperplastic goiters were observed frequently in female rats of Wistar strain when given defatted soybean under iodine deficiency for 6 to 12 months. The findings in the thyroid were those of malignant tumors in which the features of thyroid carcinomas were seen, accompanied with metastasis in the lungs of some animals. Enlargement of the thyroid was completely inhibited in rats when a small amount of iodine was added to the diet. The role of soybean factor(s) which causes enlargment of the thyroid is discussed in relation to the development of malignant goiter, together with pathological findings in the animals.
当在缺碘情况下给Wistar品系的雌性大鼠喂食脱脂大豆6至12个月时，经常观察到甲状腺增生性肿大。甲状腺的表现为出现具有甲状腺癌特征的恶性肿瘤，部分动物肺部有转移。当在饮食中添加少量碘时，大鼠甲状腺的肿大被完全抑制。结合动物的病理结果，讨论了导致甲状腺肿大的大豆因子在恶性甲状腺肿发生中的作用。
