Saillenfait A M, Bonnet P, Gallissot F, Protois J C, Peltier A, Fabriès J F
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Toxicol Sci. 1999 Apr;48(2):240-54. doi: 10.1093/toxsci/48.2.240.
The developmental toxicities of seven acrylates were studied in Sprague-Dawley rats after inhalation exposure for 6 h/day, during days 6 to 20 of gestation. The exposure concentrations were: for acrylic acid, 50, 100, 200, or 300 ppm; for methyl acrylate, 25, 50, or 100 ppm; for ethyl acrylate, 25, 50, 100, or 200 ppm; for butyl acrylate, 100, 200, or 300 ppm; for ethylhexyl acrylate, 50, 75, or 100 ppm; for hydroxyethyl acrylate, 1, 5, or 10 ppm; and for hydroxypropyl acrylate, 1, 5, or 10 ppm. No treatment-related increases in embryo/fetal mortality or fetal malformations were observed after exposure to any of these acrylates. Fetal toxicity, indicated by reduced fetal body weight, was observed after exposure to 300 ppm acrylic acid, 100 ppm methyl acrylate, 200 ppm ethyl acrylate, and 200 or 300 ppm butyl acrylate in the presence of overt signs of maternal toxicity. While there was evidence of maternal toxicity, no significant developmental toxic effects were observed after exposure to ethylhexyl acrylate, hydroxyethyl acrylate, or hydroxypropyl acrylate at any concentration. These results indicate that inhaled acrylic acid, methyl acrylate, ethyl acrylate, butyl acrylate, ethylhexyl acrylate, hydroxyethyl acrylate, and hydroxypropyl acrylate are not selectively toxic to the embryo or fetus.
在妊娠第6至20天，对斯普拉格-道利大鼠进行每天6小时的吸入暴露，研究了七种丙烯酸酯的发育毒性。暴露浓度分别为：丙烯酸，50、100、200或300 ppm；丙烯酸甲酯，25、50或100 ppm；丙烯酸乙酯，25、50、100或200 ppm；丙烯酸丁酯，100、200或300 ppm；丙烯酸2-乙基己酯，50、75或100 ppm；丙烯酸羟乙酯，1、5或10 ppm；丙烯酸羟丙酯，1、5或10 ppm。暴露于这些丙烯酸酯中的任何一种后，均未观察到与处理相关的胚胎/胎儿死亡率增加或胎儿畸形。在出现明显母体毒性迹象的情况下，暴露于300 ppm丙烯酸、100 ppm丙烯酸甲酯、200 ppm丙烯酸乙酯和200或300 ppm丙烯酸丁酯后，观察到胎儿毒性，表现为胎儿体重减轻。虽然有母体毒性的证据，但在任何浓度下暴露于丙烯酸2-乙基己酯、丙烯酸羟乙酯或丙烯酸羟丙酯后，均未观察到明显的发育毒性作用。这些结果表明，吸入的丙烯酸、丙烯酸甲酯、丙烯酸乙酯、丙烯酸丁酯、丙烯酸2-乙基己酯、丙烯酸羟乙酯和丙烯酸羟丙酯对胚胎或胎儿没有选择性毒性。
