Reininghaus W, Koestner A, Klimisch H J
Institut für Biologische Forschung, Köln, Germany.
Food Chem Toxicol. 1991 May;29(5):329-39. doi: 10.1016/0278-6915(91)90204-k.
No exposure-related clinical signs or lesions of systemic toxicity and no oncogenic responses were observed in male and female Sprague-Dawley rats exposed by inhalation to methyl acrylate (MA) or n-butyl acrylate (BA) vapours, at concentrations of 0, 15, 45 and 135 ppm. The rats were whole-body-exposed 6 hr/day, 5 days/wk, for 24 consecutive months. There was a 6-month post-exposure observation period for subgroups of BA-exposed rats. Atrophy of the neurogenic epithelial cells and hyperplasia of reserve cells were observed in the nasal mucosa of all MA- and BA-exposed groups. These changes were dose related and mainly affected the anterior part of the olfactory epithelium. Opacity and neovascularization of the cornea were seen in all MA-exposed groups and in the group exposed to 135 ppm BA. These toxic effects of the olfactory epithelium and cornea were attributed to the known irritancy of MA and BA. In the BA subgroups kept for a 6-month post-exposure observation, reconstructive effects, such as replacement of altered olfactory epithelium with respiratory epithelium, and partial regression of corneal neovascularization were observed.
在吸入浓度为0、15、45和135 ppm的丙烯酸甲酯（MA）或丙烯酸正丁酯（BA）蒸气的雄性和雌性斯普拉格-道利大鼠中，未观察到与暴露相关的全身毒性临床体征或病变，也未观察到致癌反应。大鼠每天全身暴露6小时，每周5天，连续暴露24个月。对暴露于BA的大鼠亚组进行了6个月的暴露后观察期。在所有暴露于MA和BA的组的鼻黏膜中均观察到神经源性上皮细胞萎缩和储备细胞增生。这些变化与剂量相关，主要影响嗅上皮的前部。在所有暴露于MA的组和暴露于135 ppm BA的组中均观察到角膜混浊和新生血管形成。嗅上皮和角膜的这些毒性作用归因于MA和BA已知的刺激性。在暴露后保留6个月观察期的BA亚组中，观察到了重建效应，如用呼吸上皮替代改变的嗅上皮，以及角膜新生血管的部分消退。
