Saillenfait A M, Bonnet P, Gallissot F, Peltier A, Fabriès J F
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Toxicol Sci. 1999 Jul;50(1):136-45. doi: 10.1093/toxsci/50.1.136.
The developmental toxicities of 4 methacrylates were studied in Sprague-Dawley rats after inhalation exposure for 6 h/day, during days 6 to 20 of gestation. The exposure concentrations were, for methacrylic acid, 0, 50, 100, 200, or 300 ppm; for ethyl methacrylate, 0, 600, 1200, 1800, or 2400 ppm; for n-butyl methacrylate, 0, 100, 300, 600, or 1200 ppm; and for allyl methacrylate, 0, 12, 25, 50, or 100 ppm. No significant increases in embryo/fetal lethality or fetal malformations were observed after exposure to any of these methacrylates. Fetal toxicity evidenced by statistically significant decreases in fetal body weights was observed at exposure levels > or = 1200 ppm ethyl methacrylate, > or = 600 ppm n-butyl methacrylate, and at 100 ppm allyl methacrylate. Statistically significant increases in the incidence of fetuses with skeletal variations and of fetuses with any variations were noted at 1200 ppm n-butyl methacrylate. These developmental effects were observed in the presence of overt signs of maternal toxicity. While maternal toxicity was observed, methacrylic acid caused no evidence of developmental toxicity up to 300 ppm.
在妊娠第6至20天，对斯普拉格 - 道利大鼠进行每天6小时的吸入暴露，研究了4种甲基丙烯酸酯的发育毒性。甲基丙烯酸的暴露浓度为0、50、100、200或300 ppm；甲基丙烯酸乙酯的暴露浓度为0、600、1200、1800或2400 ppm；甲基丙烯酸正丁酯的暴露浓度为0、100、300、600或1200 ppm；甲基丙烯酸烯丙酯的暴露浓度为0、12、25、50或100 ppm。暴露于这些甲基丙烯酸酯中的任何一种后，均未观察到胚胎/胎儿致死率或胎儿畸形有显著增加。在暴露水平≥1200 ppm甲基丙烯酸乙酯、≥600 ppm甲基丙烯酸正丁酯以及100 ppm甲基丙烯酸烯丙酯时，观察到胎儿体重出现统计学上显著下降，证明存在胎儿毒性。在1200 ppm甲基丙烯酸正丁酯时，观察到骨骼变异胎儿和任何变异胎儿的发生率有统计学上的显著增加。这些发育影响是在出现明显母体毒性迹象的情况下观察到的。虽然观察到了母体毒性，但甲基丙烯酸在高达300 ppm时未引起发育毒性的证据。
