Kato F, Saga K, Morimoto Y, Kaneko R
Department of Dermatology, Sapporo Medical University School of Medicine, Minami 1 Nishi 16, Chyuo-ku, Sapporo 060-8543, Japan.
Br J Dermatol. 1999 Jun;140(6):1110-3. doi: 10.1046/j.1365-2133.1999.02912.x.
We studied pilocarpine-induced cholinergic sweating, emotional sweating and sympathetic reflex sweating in atopic dermatitis (AD) patients. Secreted sweat was measured both with equipment that continuously records sweat rate and with a filter paper method that measures sweat weight absorbed. Comparison of the two methods revealed that the filter paper method underestimated the sweat secretion in AD patients. While AD patients showed no significant abnormalities in emotional sweating and sympathetic reflex sweating, the duration of pilocarpine-induced sweating was prolonged. The time from the maximal sweat rate until the sweat rate fell to half of the maximal rate was significantly longer in AD patients than in control subjects. In contrast, the time from the beginning of sweat secretion until the maximal sweat rate was not significantly different between AD patients and control subjects. There was no significant difference between AD patients and control subjects in sweat volume secreted in 20 min after pilocarpine iontophoresis. In AD patients, the total sweat volume secreted after pilocarpine iontophoresis was greater than in control subjects, although not significantly. These results suggest that the system of deactivation of pilocarpine-induced sweat secretion is impaired in AD patients whereas the activation system is not altered.
我们研究了毛果芸香碱诱导的胆碱能性出汗、情绪性出汗和交感反射性出汗在特应性皮炎（AD）患者中的情况。采用连续记录出汗率的设备和测量滤纸吸收汗液重量的方法来测量分泌的汗液。两种方法的比较显示，滤纸法低估了AD患者的汗液分泌。虽然AD患者在情绪性出汗和交感反射性出汗方面无明显异常，但毛果芸香碱诱导出汗的持续时间延长。AD患者从最大出汗率到出汗率降至最大率一半的时间明显长于对照组。相比之下，AD患者和对照组从汗液分泌开始到最大出汗率的时间无显著差异。毛果芸香碱离子导入后20分钟内分泌的汗液量在AD患者和对照组之间无显著差异。在AD患者中，毛果芸香碱离子导入后分泌的总汗液量虽未显著高于对照组，但大于对照组。这些结果表明，AD患者中毛果芸香碱诱导的汗液分泌失活系统受损，而激活系统未改变。
