Hjortskov N, Jepsen L T, Nielsen B, Juul A, Skakkebaek N E
August Krogh Institute, University of Copenhagen, Denmark.
Clin Physiol. 1995 Jul;15(4):409-14. doi: 10.1111/j.1475-097x.1995.tb00530.x.
The pilocarpine iontophoresis test (P-test) is used as a predictor of the capacity to produce sweat. Therefore, we studied the reproducibility of this test in 12 normal subjects on 10 consecutive days. Furthermore, we determined whether the P-test reflects whole-body and regional sweat secretion during exercise in the heat. Finally, we determined whether the P-test stimulates the eccrine sweat glands to maximal sweat secretion. Six growth hormone-deficient (GHD) patients who are known to have decreased sweating, and 11 healthy control subjects were studied. To induce maximal sweat secretion, the patients exercised on a bicycle ergometer at a workload corresponding to 40% of their maximal aerobic power (VO2max). The 11 healthy subjects exercised at a workload of 150 W. All subjects exercised for 60 min in ambient air at 35 degrees C, with 50% relative humidity. The P-test showed a mean day-to-day variation of 20.8% between individual subjects. There was a significant positive correlation between the P-test and regional sweat secretion (r2 = 0.74). The correlation coefficient (r2) was 0.50 for the correlation between the P-test and whole-body sweat secretion, and 0.52 for the correlation between regional sweat secretion and whole-body sweat secretion. We conclude that the pilocarpine iontophoresis test reflects heat- and exercise-induced sweating capacity. However, this test does not induce maximal sweating, and it cannot be used as a single reliable predictor of whole-body sweating, due to considerable day-to-day variation.
毛果芸香碱离子导入试验（P 试验）被用作出汗能力的预测指标。因此，我们对 12 名正常受试者连续 10 天研究了该试验的可重复性。此外，我们确定 P 试验是否反映热环境中运动期间的全身和局部出汗分泌情况。最后，我们确定 P 试验是否能刺激小汗腺达到最大出汗分泌。研究了 6 名已知出汗减少的生长激素缺乏（GHD）患者和 11 名健康对照受试者。为诱导最大出汗分泌，患者在自行车测力计上以相当于其最大有氧功率（VO2max）40%的工作量进行运动。11 名健康受试者以 150 W 的工作量进行运动。所有受试者在 35 摄氏度、相对湿度 50%的环境空气中运动 60 分钟。P 试验显示个体受试者之间的平均每日变化为 20.8%。P 试验与局部出汗分泌之间存在显著正相关（r2 = 0.74）。P 试验与全身出汗分泌之间的相关系数（r2）为 0.50，局部出汗分泌与全身出汗分泌之间的相关系数为 0.52。我们得出结论，毛果芸香碱离子导入试验反映了热和运动诱导的出汗能力。然而，该试验不能诱导最大出汗，并且由于每日变化较大，不能用作全身出汗的单一可靠预测指标。
