Vimieiro-Gomes A C, Magalhães F C, Amorim F T, Machado-Moreira C A, Rosa M S, Lima N R V, Rodrigues L O C
Laboratório de Fisiologia do Exercício, Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Braz J Med Biol Res. 2005 Jul;38(7):1133-9. doi: 10.1590/s0100-879x2005000700017. Epub 2005 Jul 4.
Centrally stimulated sweat rate produced by graded exercise until exhaustion was compared to the local sweat rate induced by pilocarpine, often used as a sweating index for healthy individuals. Nine young male volunteers (22 +/- 4 years) were studied in temperate environment in two situations: at rest and during progressive exercise with 25 W increases every 2 min until exhaustion, on a cycle ergometer. In both situations, sweating was induced on the right forearm with 5 ml 0.5% pilocarpine hydrochloride applied by iontophoresis (1.5 mA, 5 min), with left forearm used as control. Local sweat rate was measured for 15 min at rest. During exercise, whole-body sweat rate was calculated from the body weight variation. Local sweat rate was measured from the time when heart rate reached 150 bpm until exhaustion and was collected using absorbent filter paper. Pharmacologically induced local sweat rate at rest (0.4 +/- 0.2 mg cm-2 min-1) and mean exercise-induced whole-body sweat rate (0.4 +/- 0.1 mg cm-2 min-1) were the same (P > 0.05) but were about five times smaller than local exercise-induced sweat rate (control = 2.1 +/- 1.4; pilocarpine = 2.7 +/- 1.2 mg cm-2 min-1), indicating different sudorific mechanisms. Both exercise-induced whole-body sweat rate (P < 0.05) and local sweat rate (P < 0.05) on control forearm correlated positively with pilocarpine-induced local sweat rate at rest. Assuming that exercise-induced sweating was a result of integrated physiological mechanisms, we suggest that local and whole-body sweat rate measured during graded exercise could be a better sweating index than pilocarpine.
将分级运动直至 exhaustion 时中枢刺激产生的出汗率与毛果芸香碱诱导的局部出汗率进行比较，毛果芸香碱常用于作为健康个体的出汗指标。九名年轻男性志愿者（22±4岁）在温带环境下的两种情况下进行了研究：休息时和在自行车测力计上进行渐进性运动，每2分钟增加25瓦直至 exhaustion。在这两种情况下，通过离子电渗疗法（1.5毫安，5分钟）在右前臂涂抹5毫升0.5%盐酸毛果芸香碱诱导出汗，左前臂作为对照。休息时测量局部出汗率15分钟。运动期间，根据体重变化计算全身出汗率。从心率达到150次/分钟直至 exhaustion 时测量局部出汗率，并使用吸水滤纸收集。休息时药物诱导的局部出汗率（0.4±0.2毫克/平方厘米·分钟）和运动诱导的平均全身出汗率（0.4±0.1毫克/平方厘米·分钟）相同（P>0.05），但比运动诱导的局部出汗率小约五倍（对照=2.1±1.4；毛果芸香碱=2.7±1.2毫克/平方厘米·分钟），表明出汗机制不同。对照前臂的运动诱导全身出汗率（P<0.05）和局部出汗率（P<0.05）均与休息时毛果芸香碱诱导的局部出汗率呈正相关。假设运动诱导出汗是综合生理机制的结果，我们建议在分级运动期间测量的局部和全身出汗率可能是比毛果芸香碱更好的出汗指标。
