Baldursson B T, Hedblad M A, Beitner H, Lindelöf B
Department of Dermatology, Gävle Hospital, 801 87 Gävle, Sweden.
Br J Dermatol. 1999 Jun;140(6):1148-52. doi: 10.1046/j.1365-2133.1999.02879.x.
We have studied 25 cases of squamous cell carcinoma in chronic venous leg ulcers. Twenty-three of the patients were dead and two were alive. The mean age at cancer diagnosis was 78.5 years. The median survival was 1 year. Eleven tumours were well-differentiated, 10 moderately and four poorly. All patients with a poorly differentiated tumour died within a year. Metastases were certain in eight cases. The disease was lethal in 10 cases which included all poorly differentiated tumours. The survival of the study group was significantly shortened compared with a control group of patients with lower limb non-melanoma skin cancer (n = 433) from the Swedish Cancer Registry (P = 0.0084). When diagnosed, squamous cell carcinoma in chronic leg ulcers merits a thorough investigation of the degree of differentiation and spread. Assertive treatment is indicated as poorly differentiated tumours and some moderately differentiated tumours may be fatal.
我们研究了25例小腿慢性静脉溃疡鳞状细胞癌患者。其中23例患者已死亡，2例存活。癌症诊断时的平均年龄为78.5岁。中位生存期为1年。11例肿瘤为高分化，10例为中分化，4例为低分化。所有低分化肿瘤患者均在1年内死亡。8例确诊有转移。10例患者因该病死亡，其中包括所有低分化肿瘤。与瑞典癌症登记处下肢非黑色素瘤皮肤癌对照组（n = 433）相比，研究组的生存期显著缩短（P = 0.0084）。慢性腿部溃疡鳞状细胞癌确诊时，值得对分化程度和扩散情况进行全面调查。鉴于低分化肿瘤和一些中分化肿瘤可能致命，应采取积极治疗。
