Mantovani A
Istituto di Ricerche Farmacologiche 'Mario Negri', Via Eritrea 62-20157 Milan Italy.
Immunol Today. 1999 Jun;20(6):254-7. doi: 10.1016/s0167-5699(99)01469-3.
Chemokines are redundant in their action on target cells and promiscuous in receptor usage. Moreover, certain cells concomitantly produce several chemokines with an overlapping spectrum of action. Here, Alberto Mantovani argues that such robustness provides a conceptual framework to understand these intriguing aspects of the chemokine system.
趋化因子对靶细胞的作用具有冗余性，且在受体使用上具有混杂性。此外，某些细胞会同时产生几种具有重叠作用谱的趋化因子。在此，阿尔贝托·曼托瓦尼认为，这种稳健性为理解趋化因子系统的这些有趣方面提供了一个概念框架。
