Yang J, Kornbluth S
Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3686, C366 LSRC, Durham, NC 27710, USA.
Trends Cell Biol. 1999 Jun;9(6):207-10. doi: 10.1016/s0962-8924(99)01577-9.
Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK-cyclins). Although the enzymatic activity of these complexes is regulated tightly, it has recently been demonstrated that an additional facet of cell-cycle control involves the modulation of CDK-cyclin subcellular localization. Recent discoveries include the identification of nuclear transport factors responsible for ferrying some of the CDK-cyclins in and out of the nucleus, the demonstration that phosphorylation can regulate these transport processes and the establishment of potential links between cell-cycle checkpoints and the control of CDK-cyclin subcellular localization.
细胞周期的进程由细胞周期蛋白依赖性激酶复合物（CDK-细胞周期蛋白）的周期性激活和失活所调控。尽管这些复合物的酶活性受到严格调节，但最近已证明细胞周期控制的另一个方面涉及CDK-细胞周期蛋白亚细胞定位的调节。最近的发现包括鉴定负责将一些CDK-细胞周期蛋白运入和运出细胞核的核转运因子，证明磷酸化可调节这些转运过程，以及建立细胞周期检查点与CDK-细胞周期蛋白亚细胞定位控制之间的潜在联系。
