Serrador J M, Nieto M, Sánchez-Madrid F
Servico de Immunolog a, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Trends Cell Biol. 1999 Jun;9(6):228-33. doi: 10.1016/s0962-8924(99)01553-6.
T lymphocytes have an inherent ability to migrate along a chemotactic gradient, which enables them to exit the bloodstream and reach different tissues. Motile T cells display a polarized morphology with two distinct cell compartments: the leading edge and the uropod. During cell polarization, chemoattractant receptors, cell-adhesion molecules and cytoskeletal proteins are redistributed within these cellular compartments. The polarity of T lymphocytes changes during the establishment of antigen-specific cell-cell interactions, and this involves rearrangement of cytoskeletal proteins. This article discusses the regulation of these cytoskeletal rearrangements, and their role in the activation, migration and effector function of T cells.
T淋巴细胞具有沿趋化梯度迁移的内在能力，这使它们能够离开血液并到达不同组织。运动性T细胞呈现出极化形态，具有两个不同的细胞区室：前沿和尾足。在细胞极化过程中，趋化因子受体、细胞粘附分子和细胞骨架蛋白在这些细胞区室内重新分布。在抗原特异性细胞间相互作用建立过程中，T淋巴细胞的极性会发生变化，这涉及细胞骨架蛋白的重排。本文讨论了这些细胞骨架重排的调节及其在T细胞活化、迁移和效应功能中的作用。
