Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.
Department of Biology, University of Konstanz, Konstanz, Germany.
Front Immunol. 2018 Nov 15;9:2638. doi: 10.3389/fimmu.2018.02638. eCollection 2018.
T cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell migration and activation also take place in distinct mechanical environments and lead to drastic morphological changes and reorganization of the acto-myosin cytoskeleton. In this review we discuss how adhesion proteins and the T cell receptor act as mechanosensors to translate these mechanical contexts into signaling events. We further discuss how cell tension could bring a significant contribution to the regulation of T cell signaling and function.
T 细胞从血液迁移到淋巴器官和组织中，以及在其中的迁移和激活，依赖于复杂的生化信号事件。但是 T 细胞的迁移和激活也发生在不同的力学环境中，导致肌动球蛋白细胞骨架的剧烈形态变化和重组。在这篇综述中，我们讨论了粘附蛋白和 T 细胞受体如何作为机械感受器，将这些力学环境转化为信号事件。我们还进一步讨论了细胞张力如何对 T 细胞信号转导和功能的调节做出重要贡献。
