水稻对大鼠抗过敏作用的评估。

The evaluation of antianaphylactic effect of Oryza sativa L. in rats.

作者信息

Kim H M, Yi D K, Shin H Y

机构信息

Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, Korea.

出版信息

Am J Chin Med. 1999;27(1):63-71. doi: 10.1142/S0192415X99000094.

DOI:10.1142/S0192415X99000094

PMID:10354818

Abstract

This study was carried out to examine the effect of methanol extract of Oryza sativa L. (Dong-Jin in Korean, abbreviate as Os-DJ hereafter) on anaphylaxis. Os-DJ (10(-5) to 1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in rats. When Os-DJ was pretreated at concentration ranging from 10(-5) to 1 g/kg, the serum histamine levels were reduced in a dose-dependent manner. Os-DJ (1 g/kg) also significantly inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, Os-DJ dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. These results indicate that Os-DJ possess antianaphylactic activity by inhibition of histamine release from mast cells in vivo and in vitro.

摘要

本研究旨在考察水稻（韩国名为Dong-Jin，以下简称为Os-DJ）甲醇提取物对过敏反应的影响。Os-DJ（10⁻⁵至1 g/kg）剂量依赖性地抑制了化合物48/80诱导的大鼠全身性过敏反应。当以10⁻⁵至1 g/kg的浓度预处理Os-DJ时，血清组胺水平呈剂量依赖性降低。Os-DJ（1 g/kg）也显著抑制了由抗二硝基苯基（DNP）IgE激活的局部过敏反应。此外，Os-DJ剂量依赖性地抑制了由化合物48/80或抗DNP IgE激活的大鼠腹膜肥大细胞（RPMC）的组胺释放。这些结果表明，Os-DJ通过在体内和体外抑制肥大细胞释放组胺而具有抗过敏活性。