榆根皮提取物对大鼠全身及局部过敏反应的作用。

Action of Ulmi radicis cortex extract on systemic and local anaphylaxis in rats.

Kim H M, Shin H Y, Choi I Y, Lee E H, Lee E J

Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.

Gen Pharmacol. 1998 Sep;31(3):483-8. doi: 10.1016/s0306-3623(98)00003-2.

Abstract

To assess the contribution of an aqueous extract of Ulmi radicis cortex (AEURC) in systemic anaphylaxis, compound 48/80 was used as a fatal anaphylaxis inducer in rats. 2. AEURC completely inhibited anaphylactic shock with a dose of 1.0 g/kg body weight (BW) 1 hr before injection of compound 48/80. 3. AEURC significantly inhibited serum histamine levels induced by compound 48/80. 4. AEURC (1.0 g/kg BW) also inhibited by 79.1% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. 5. AEURC dose dependently inhibited the histamine release from the rat peritoneal mast cells (RPMCs) by compound 48/80. Moreover, AEURC had a significant inhibitory effect on anti-DNP IgE-induced histamine release and tumor necrosis factor-alpha production from RPMC. 6. The level of cAMP in RPMC, when AEURC was added, significantly increased compared with that of a normal control. 7. These results indicate that AEURC may possess strong antianaphylactic action.

摘要

为评估榆根皮水提取物（AEURC）在全身性过敏反应中的作用，将化合物48/80用作大鼠致命性过敏反应诱导剂。2. 在注射化合物48/80前1小时，AEURC以1.0 g/kg体重（BW）的剂量完全抑制了过敏性休克。3. AEURC显著抑制了化合物48/80诱导的血清组胺水平。4. AEURC（1.0 g/kg BW）还抑制了由抗二硝基苯基（DNP）IgE激活的79.1%的被动皮肤过敏反应。5. AEURC剂量依赖性地抑制化合物48/80诱导的大鼠腹膜肥大细胞（RPMC）组胺释放。此外，AEURC对RPMC中抗DNP IgE诱导的组胺释放和肿瘤坏死因子-α产生具有显著抑制作用。6. 添加AEURC时，RPMC中的cAMP水平与正常对照组相比显著升高。7. 这些结果表明AEURC可能具有强大的抗过敏作用。