Thomsen H S, Morcos S K
Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Denmark.
Eur Radiol. 1999;9(4):738-40. doi: 10.1007/s003300050746.
The purpose of this study was to establish guidelines on how to avoid metformin-induced lactic acidosis following intravascular use of contrast media. We reviewed articles published in international journals. No conclusive evidence was found to indicate that the intravascular use of contrast media precipitated the development of metformin-induced lactic acidosis in patients with normal S-creatinine (< 130 mumol/l). The complication was almost always observed in non-insulin-dependent diabetic patients with decreased renal function before injection of contrast media. Guidelines for the use of contrast media in this group of patients are proposed.
本研究的目的是制定关于如何避免血管内使用造影剂后二甲双胍诱发乳酸性酸中毒的指南。我们查阅了国际期刊上发表的文章。未发现确凿证据表明，血管内使用造影剂会促使血清肌酐正常（<130 μmol/L）的患者发生二甲双胍诱发的乳酸性酸中毒。几乎总是在注射造影剂前肾功能减退的非胰岛素依赖型糖尿病患者中观察到这种并发症。本文提出了针对这类患者使用造影剂的指南。
