Steinmann A, Gummer M, Agathos M, Breit R
Abteilung für Dermatologie und Allergologie, Städt. Krankenhaus München-Schwabing, Akademisches Lehrkrankenhaus des Ludwig-Maximilians-Universität München.
Hautarzt. 1999 Apr;50(4):270-4. doi: 10.1007/s001050050900.
Palpable arciform migratory erythema of Clark (PAME) has been described as a rare member in the group of T-cell pseudolymphoma. The clinical picture of infiltrated annular erythema developing into large migrating lesions with the trunk as predilection site is distinctive from other pseudolymphomas. Because of the very similar histology and immunohistochemistry in comparison to the more frequent lymphocytic infiltration of the skin of Jessner and Kanof (LIS) doubts have been raised about the existence of PAME as an unique entity. A 46-year old patient presented with the typical picture of PAME on his trunk while showing typical lesions of LIS on his neck and face. Both diseases showed synchronous intermittent remissions in response to different therapeutic modalities. Multiple biopsies were subsequently performed and histological, immunohistochemical and molecular biological examinations did not reveal relevant differences between PAME and LIS in this patient. We conclude that the findings in this key case suggest that the T-cell pseudolymphoma PAME is not an unique entity, but a special clinical presentation of LIS.
克拉克可触及的弧形游走性红斑（PAME）已被描述为T细胞假性淋巴瘤组中的罕见成员。浸润性环状红斑发展为以躯干为好发部位的大型游走性病变的临床表现与其他假性淋巴瘤不同。由于与更常见的耶斯纳和卡诺夫皮肤淋巴细胞浸润（LIS）相比，其组织学和免疫组化非常相似，因此有人对PAME作为一种独特实体的存在提出了质疑。一名46岁患者躯干出现典型的PAME表现，同时颈部和面部出现典型的LIS病变。两种疾病对不同治疗方式均呈现同步间歇性缓解。随后进行了多次活检，组织学、免疫组化和分子生物学检查未发现该患者的PAME和LIS之间存在相关差异。我们得出结论，该关键病例的研究结果表明，T细胞假性淋巴瘤PAME不是一个独特的实体，而是LIS的一种特殊临床表现。
