Abeck D, Ollert M W, Eckert F, Szeimies R M, Tiemann M, Braun-Falco O, Steinkraus V, Ring J
Department of Dermatology, Universität-Krankenhaus Eppendorf, Hamburg,Germany.
Arch Dermatol. 1997 Jun;133(6):763-6. doi: 10.1001/archderm.133.6.763.
Palpable migratory arciform erythema is clinically characterized by sharply circumscribed, infiltrated erythematous patches that tend to spread irregularly, resulting in arciform morphologic features. The histopathologic features are characterized by a patchy inflammatory perivascular and periadnexal T-lymphocytic infiltrate throughout the dermis. The disease runs a chronic course and is rarely described in the literature.
Three middle-aged patients of both sexes had palpable migratory arciform erythema with 1, several, or multiple lesions on the trunk. There was a dense perivascular and periadnexal, predominantly lymphocytic infiltrate of the reticular dermis without any interstitial distribution of inflammatory cells. Absence of mucin deposits and plasma cells was a striking feature. The immunohistochemical profile showed an infiltrate dominated by T cells of polyclonal origin. In addition, polyclonal B cells and histiocytes were present in small numbers. In all 3 cases, oral antibacterial treatment resulted in a complete (2 patients) or temporary (1 patient) resolution of skin lesions.
Palpable migratory arciform erythema shows distinctive differences in clinical and pathological features and treatment in contrast to other diseases with cutaneous lymphocytic infiltrates, including lymphocytic infiltration of Jessner and Kanof. Therefore, it is likely a distinct disease entity.
可触及的游走性弧形红斑的临床特征为边界清晰、浸润性红斑斑块，倾向于不规则扩散，形成弧形形态特征。组织病理学特征为真皮全层散在性血管周围和附件周围T淋巴细胞浸润。该病病程呈慢性，文献中鲜有描述。
3例中年男女患者躯干出现可触及的游走性弧形红斑，有1个、数个或多个皮损。网状真皮有密集的血管周围和附件周围浸润，主要为淋巴细胞浸润，炎症细胞无间质分布。无黏蛋白沉积和浆细胞是一个显著特征。免疫组化显示浸润以多克隆来源的T细胞为主。此外，有少量多克隆B细胞和组织细胞。所有3例患者经口服抗菌治疗后，皮损完全消退（2例）或暂时消退（1例）。
与其他皮肤淋巴细胞浸润性疾病（包括杰斯纳和卡诺夫淋巴细胞浸润症）相比，可触及的游走性弧形红斑在临床、病理特征及治疗方面有明显差异。因此，它可能是一种独特的疾病实体。
