Salomon N, Walchner M, Messer G, Plewig G, Röcken M
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
Hautarzt. 1999 Apr;50(4):275-9. doi: 10.1007/s001050050901.
Sixteen patients with generalized granuloma anulare and two patients with localized granuloma anulare received bath-PUVA therapy. Their lesions previously had not responded to conventional therapy. After an average of 55 (11 to 61) treatments and a mean cumulative dose of 69.5 (7.1 to 261.5) J/cm2, complete remission was observed in 5 patients and a clear improvement in 10 patients. Three patients stopped therapy after few treatments. Recurrent lesions appeared in 4 patients; in three of them reinitiation of the bath-PUVA-therapy again led to complete remission. Maintenance therapy for several months may be useful for patients suffering from relapsing granuloma anulare. Potential risks of long-lasting bath-PUVA therapy should be taken into consideration.
16例泛发性环状肉芽肿患者和2例局限性环状肉芽肿患者接受了水浴补骨脂素紫外线A光化学疗法（bath-PUVA疗法）。他们的皮损先前对传统治疗无反应。平均经过55次（11至61次）治疗，平均累积剂量为69.5 J/cm²（7.1至261.5 J/cm²）后，5例患者完全缓解，10例患者明显改善。3例患者在接受几次治疗后停止治疗。4例患者出现复发性皮损；其中3例再次开始水浴补骨脂素紫外线A光化学疗法后再次完全缓解。对于复发性环状肉芽肿患者，持续数月的维持治疗可能有效。应考虑长期水浴补骨脂素紫外线A光化学疗法的潜在风险。
