Harth W, Richard G
Haut- und Poliklinik, Medizinischen Hochschule Erfurt.
Hautarzt. 1993 Nov;44(11):693-8.
We report on four patients with granuloma annulare disseminatum successfully treated with etretinate as basic medication. In two cases there was complete remission after treatment with initial doses of up to 0.9 mg/kg body weight etretinate. One patient did not respond to etretinate alone but the condition was cured when Re-PUVA therapy was administered in addition. In another patient, with widespread granuloma annulare, primary treatment with Re-PUVA was instigated, followed by low-dose monotherapy with etretinate. According to these findings, we propose a three-stage regimen of therapy. After checking that the indications are appropriate, we first initiate monotherapy with etretinate and switch to a low-dose treatment over a longer period on response. If there is no response we switch to the second stage, i.e. Re-PUVA therapy; the third is then etretinate monotherapy to prevent relapse.
我们报告了4例播散性环状肉芽肿患者，以阿维A酯作为基础药物成功治愈。其中2例患者在初始剂量高达0.9mg/kg体重的阿维A酯治疗后完全缓解。1例患者单独使用阿维A酯无效，但加用补骨脂素长波紫外线（Re-PUVA）疗法后治愈。另1例广泛播散性环状肉芽肿患者，首先采用Re-PUVA进行初始治疗，随后采用低剂量阿维A酯单药治疗。根据这些发现，我们提出了一个三阶段治疗方案。在确认适应证合适后，我们首先启动阿维A酯单药治疗，根据反应情况在较长时间内转为低剂量治疗。如果没有反应，则进入第二阶段，即Re-PUVA治疗；第三阶段则是阿维A酯单药治疗以预防复发。
