He D S, Sharma P, Wang X, Bosnos M, Marcus F I
University of Arizona, Tucson, USA.
J Interv Card Electrophysiol. 1999 Mar;3(1):69-77. doi: 10.1023/a:1009883825242.
The aim of this study was to determine if the bio-battery signal can predict myocardial lesion formation and depth.
Fresh bovine ventricular myocardium was immersed in a temperature-controlled bath of circulating blood. RF energy was delivered with a custom generator to a catheter electrode. RF energy, electrode temperature, bio-battery signal and tissue impedance were displayed and recorded. A copper return plate was placed in the bath.
When 50 volts of constant RF energy was terminated at a 20, 40, or 60% decline from the maximum bio-battery signal, the lesion depth was 4 +/- 0.4 mm. When RF energy application was terminated later, at a point characterized by a brief change of slope of the bio-battery signal, the lesions measured 7.8 +/- 1.4 mm in depth. This "bump" occurred before a rapid impedance rise.
The depth of lesions created at the "bump" point was almost two-fold deeper than those at the termination points of 20, 40 and 60% bio-battery decrease (p = 0.0001). When RF energy was terminated at the rapid impedance rise the lesions were similar in depth, 8.2 +/- 0.9 mm, to those obtained when RF energy was stopped at the "bump" (p = 0.28). The bio-battery signal provides a unique marker that might be useful to obtain maximum lesion depth while avoiding rapid impedance rise.
本研究旨在确定生物电池信号是否能够预测心肌损伤的形成及深度。
将新鲜牛心室心肌浸入温度可控的循环血液浴槽中。通过定制发生器向导管电极输送射频能量。显示并记录射频能量、电极温度、生物电池信号及组织阻抗。在浴槽中放置一块铜制回路板。
当50伏恒定射频能量在生物电池信号最大值下降20%、40%或60%时终止施加，损伤深度为4±0.4毫米。当射频能量施加在生物电池信号斜率短暂变化的点之后终止时，测得损伤深度为7.8±1.4毫米。这种“凸起”出现在阻抗快速上升之前。
在“凸起”点产生的损伤深度几乎是生物电池信号下降20%、40%和60%时终止施加射频能量所产生损伤深度的两倍（p = 0.0001）。当在阻抗快速上升时终止射频能量施加，损伤深度与在“凸起”点停止射频能量施加时相似，为8.2±0.9毫米（p = 0.28）。生物电池信号提供了一个独特的标志物，可能有助于在避免阻抗快速上升的同时获得最大损伤深度。
