Sethi J K, Hotamisligil G S
Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA.
Semin Cell Dev Biol. 1999 Feb;10(1):19-29. doi: 10.1006/scdb.1998.0273.
Tumor necrosis factor-alpha (TNF alpha) is a multifunctional cytokine which exerts a myriad of biological actions in different tissues and species. Many of these actions can perturb the normal regulation of energy metabolism. In adipose tissue, in particular, TNF alpha has been demonstrated to regulate or interfere with adipocyte metabolism at numerous sites including transcriptional regulation, glucose and fatty acid metabolism and hormone receptor signaling. The implications of these perturbations in disease states and the current understanding of the molecular mechanisms utilised by TNF alpha are discussed herein.
肿瘤坏死因子-α(TNFα)是一种多功能细胞因子,在不同组织和物种中发挥着多种生物学作用。其中许多作用会干扰能量代谢的正常调节。特别是在脂肪组织中,TNFα已被证明在多个位点调节或干扰脂肪细胞代谢,包括转录调节、葡萄糖和脂肪酸代谢以及激素受体信号传导。本文讨论了这些干扰在疾病状态中的影响以及目前对TNFα所利用分子机制的理解。