Olszanecka-Glinianowicz Magdalena, Zahorska-Markiewicz Barbara, Zurakowski Aleksander, Glinianowicz Mariusz
Katedry Patofizjologii Sla,skiej Akademii Medycznej, Katowicach.
Wiad Lek. 2005;58(11-12):670-4.
Tumor necrosis factor is multifunctional cytokine involved in various cell functions, such as differentiation, mitosis, angiogenesis, inflammation and immune controls. TNF-alpha plays also an important role in the control of metabolism. Its action on adipocytes includes increasing secretion of triglicerydes and inhibiting insulin action, controlling expression of some genes and modulating free fatty acid and leptin secretion. The review of the current literature on the TNF-alpha role in metabolism is presented in this paper.
肿瘤坏死因子是一种多功能细胞因子，参与多种细胞功能，如分化、有丝分裂、血管生成、炎症和免疫调控。肿瘤坏死因子-α在代谢控制中也发挥着重要作用。它对脂肪细胞的作用包括增加甘油三酯分泌、抑制胰岛素作用、控制某些基因的表达以及调节游离脂肪酸和瘦素分泌。本文对当前关于肿瘤坏死因子-α在代谢中作用的文献进行了综述。
