Høidrup S, Grønbaek M, Gottschau A, Lauritzen J B, Schroll M
Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen University Hospital.
Am J Epidemiol. 1999 Jun 1;149(11):993-1001. doi: 10.1093/oxfordjournals.aje.a009760.
The authors prospectively studied the association between quantity and type of alcohol intake and risk of hip fracture among 17,868 men and 13,917 women. Analyses were based on pooled data from three population studies conducted in 1964-1992 in Copenhagen, Denmark. During follow-up, 500 first hip fractures were identified in women and 307 in men. A low to moderate weekly alcohol intake (1-27 drinks for men and 1-13 drinks for women) was not associated with hip fracture. Among men, the relative risk of hip fracture gradually increased for those who drank 28 drinks or more per week (relative risk (RR) = 1.75, 95% confidence interval (CI) 1.06-2.89 for 28-41 drinks; RR = 5.28, 95% CI 2.60-10.70 for 70 or more drinks) as compared with abstainers. Women who drank 14-27 drinks per week had an age-adjusted relative risk of hip fracture of 1.44 (95% CI 1.03-2.03), but the association weakened after adjustment for confounders (RR = 1.32, 95% CI 0.92-1.87). The risk of hip fracture differed according to the type of alcohol preferred: preferrers of beer had a higher risk of hip fracture (RR = 1.46, 95% CI 1.11-1.91) than preferrers of other types of alcoholic beverages. The corresponding relative risks for preferrers of wine and spirits were 0.77 (95% CI 0.58-1.03) and 0.82 (95% CI 0.58-1.14), respectively. In conclusion, an alcohol intake within the current European drinking limits does not influence the risk of hip fracture, whereas an alcohol intake of more than 27 drinks per week is a major risk factor for men.
作者前瞻性地研究了17868名男性和13917名女性的酒精摄入量及类型与髋部骨折风险之间的关联。分析基于1964年至1992年在丹麦哥本哈根进行的三项人群研究的汇总数据。在随访期间，女性中确诊500例首次髋部骨折，男性中确诊307例。每周低至中度饮酒量（男性1 - 27杯，女性1 - 13杯）与髋部骨折无关。在男性中，每周饮酒28杯或更多的人髋部骨折的相对风险逐渐增加（每周饮酒28 - 41杯时，相对风险（RR）= 1.75，95%置信区间（CI）1.06 - 2.89；每周饮酒70杯或更多时，RR = 5.28，95% CI 2.60 - 10.70），与不饮酒者相比。每周饮酒14 - 27杯的女性年龄调整后的髋部骨折相对风险为1.44（95% CI 1.03 - 2.03），但在调整混杂因素后该关联减弱（RR = 1.32，95% CI 0.92 - 1.87）。髋部骨折风险因偏好的酒精类型而异：啤酒偏好者髋部骨折风险更高（RR = 1.46，95% CI 1.11 - 1.91），高于其他类型酒精饮料偏好者。葡萄酒和烈酒偏好者的相应相对风险分别为0.77（95% CI 0.58 - 1.03）和0.82（95% CI 0.58 - 1.14）。总之，在当前欧洲饮酒限量范围内饮酒不会影响髋部骨折风险，而每周饮酒超过27杯是男性的主要风险因素。
