Fernández B, Vatta M, Rodríguez-Fermepín M, Bianciotti L, Romay S, Eizayaga F, Perazzo J, Lemberg A
Cátedras de Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Neurochem Int. 1999 Mar;34(3):177-81. doi: 10.1016/s0197-0186(98)00083-7.
Peripheral noradrenergic activity is enhanced in portal hypertension and correlates with the progression of the disease. However, little is known about the status of central norepinephrine (NE) in portal hypertension. The aim of the present work was to study the uptake of NE in several areas rich in NE in experimental prehepatic portal hypertension. The experiments were performed in vitro in several encephalic areas and nuclei, obtained according to the 'punch-out technique'. Results showed that in portal hypertensive rats NE uptake enhanced in all areas and nuclei studies (subfornical organ, organum vasculosum lamina terminalis, area postrema, locus coeruleus and nucleus tractus solitarius). The present results suggest that these encephalic areas and brainstem nuclei may be related to the development and/or maintenance of portal hypertension in this animal model.
门静脉高压症患者外周去甲肾上腺素能活性增强，且与疾病进展相关。然而，关于门静脉高压症时中枢去甲肾上腺素（NE）的状态知之甚少。本研究的目的是探讨实验性肝前性门静脉高压症时富含NE的几个脑区中NE的摄取情况。实验采用“打孔技术”在体外对多个脑区和神经核进行。结果显示，在门静脉高压大鼠中，所有研究的脑区和神经核（穹窿下器官、终板血管器、最后区、蓝斑和孤束核）中NE摄取均增强。目前的结果表明，这些脑区和脑干神经核可能与该动物模型门静脉高压症的发生和/或维持有关。
