Rasmusson L, Meredith N, Cho I H, Sennerby L
Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, Göteborg University, Sweden.
Int J Oral Maxillofac Surg. 1999 Jun;28(3):224-31.
A rabbit model was used to study the healing and stability of titanium implants in free bone grafts, placed simultaneously or after 8 weeks of healing and followed for 24 weeks. The skull bone was used as donor site and the tibial metaphysis as recipient site. Stability measurements were performed by using resonance frequency analysis (RFA) at implant placement and after 4, 8, 16 and 24 weeks of healing. Statistically significant higher resonance frequencies were measured at all time points for the delayed approach implants. Removal torque tests after 24 weeks revealed no differences between the two procedures. Histologic ground sections were prepared on specimens taken after 8, 16 and 24 weeks of healing. More bone-implant contacts were observed in the bone graft for the implants inserted in a delayed fashion, while there was no statistically significant difference in the degree of total bone-implant contact between the two groups. It is concluded that delayed implant placement in autogenous onlay bone grafts results in a better integration and stability of the implants.
采用兔模型研究钛种植体在同期植入或愈合8周后植入的游离骨移植中的愈合情况和稳定性，并随访24周。颅骨作为供骨部位，胫骨近端干骺端作为受骨部位。在种植体植入时以及愈合4、8、16和24周后，通过共振频率分析（RFA）进行稳定性测量。对于延迟植入的种植体，在所有时间点测量的共振频率在统计学上均显著更高。24周后的去除扭矩测试显示两种方法之间没有差异。在愈合8、16和24周后采集的标本上制备组织学磨片。对于延迟植入的种植体，在骨移植中观察到更多的骨-种植体接触，而两组之间的总骨-种植体接触程度没有统计学上的显著差异。得出的结论是，在自体骨膜下骨移植中延迟植入种植体可使种植体获得更好的整合和稳定性。
