Rogde S, Hilberg T, Teige B
Institute of Forensic Medicine, University of Oslo, Norway.
Forensic Sci Int. 1999 Mar 15;100(1-2):109-16. doi: 10.1016/s0379-0738(98)00184-4.
Three cases are presented in which death was caused by suicidal intoxication with moclobemide in combination with a selective serotonin reuptake inhibitor. Both antidepressant drug types are considered to be relatively safe with regard to lethal overdose. However, the combination may cause the serotonin syndrome, a condition with a high mortality rate. In one of the cases, there was clinical information consistent with the serotonin syndrome, in the two other cases, there was no information of the clinical course. Postmortem redistribution of the selective monoamine oxidase inhibitor moclobemide was investigated in a rat model. Postmortem concentrations in blood from the vena cava and the heart were found to be in good accordance with antemortem concentrations. Postmortem concentrations in vitreous humour and various tissues were also measured. The apparent volume of distribution was calculated to be 0.95 +/- 0.10 l/kg, which is in the same range as that reported in man.
本文报告了3例因服用吗氯贝胺与选择性5-羟色胺再摄取抑制剂导致自杀中毒死亡的病例。两种抗抑郁药物单独服用时过量致死的风险都相对较低。然而，两者联用可能会导致血清素综合征，这是一种死亡率很高的病症。其中1例有与血清素综合征相符的临床症状，另外2例没有关于临床病程的信息。在大鼠模型中研究了选择性单胺氧化酶抑制剂吗氯贝胺的死后再分布情况。发现腔静脉血和心脏血中的死后浓度与生前浓度高度一致。还测量了玻璃体液和各种组织中的死后浓度。计算得出的表观分布容积为0.95±0.10升/千克，与人体报告的范围相同。
