Camaris C, Little D
Department of Anatomical Pathology, Westmead Hospital, Sydney, Australia.
J Forensic Sci. 1997 Sep;42(5):954-5.
A fatality due to ingestion of the antidepressant drug moclobemide is reported. Moclobemide is a selective and reversible inhibitor of monoamine oxidase type A. Previous reports have suggested that it is a safe drug even when taken in large quantities. The few reported fatalities have all been ascribed to serotonin syndrome, due to an interaction between moclobemide and other serotonergic agents. A 48-year-old woman with a history of depression and suicide attempts was found deceased at home. Autopsy revealed no evidence of significant natural disease or injury. Toxicologic analysis was performed and drug levels measured by capillary gas chromatography. The blood concentration of moclobemide was 137 mg/L and the liver concentration was 432 mg/kg. Low levels of diazepam, nordiazepam, and trifluoperazine were also detected. Death was considered to be due to acute poisoning by moclobemide. This case report is the first, to our knowledge, where death has been attributed to the toxic effects of moclobemide alone.
据报道，有一例因摄入抗抑郁药吗氯贝胺导致死亡的案例。吗氯贝胺是一种选择性且可逆的A型单胺氧化酶抑制剂。先前的报道表明，即使大量服用它也是一种安全的药物。少数已报道的死亡案例均归因于血清素综合征，这是由于吗氯贝胺与其他血清素能药物相互作用所致。一名有抑郁症和自杀未遂史的48岁女性被发现死于家中。尸检未发现明显的自然疾病或损伤迹象。进行了毒理学分析，并通过毛细管气相色谱法测量了药物水平。吗氯贝胺的血液浓度为137毫克/升，肝脏浓度为432毫克/千克。还检测到低水平的地西泮、去甲地西泮和三氟拉嗪。死亡被认为是由吗氯贝胺急性中毒所致。据我们所知，该病例报告是首例死亡仅归因于吗氯贝胺毒性作用的案例。
