Fineschi V, Monasterolo G, Rosi R, Turillazzi E
Department of Forensic Sciences, University of Siena, Italy.
Forensic Sci Int. 1999 Mar 15;100(1-2):137-42. doi: 10.1016/s0379-0738(98)00205-9.
The Authors describe an extremely rare fatal case (sixth case in the literature) of anaphylactic shock following a fluorescein angiography. This is the first report in which the diagnosis of anaphylactic reaction to the dye was made through laboratory analyses. The diagnosis of fatal shock due to sodium fluorescein was made based on clinical, laboratory and immunohistochemical data. Mast-cell tryptase was dosed in serum and a pulmonary immunohistochemical evaluation was performed. Tryptase, a neutral protease of human mast-cells is a potentially important indicator of mast-cell involvement in anaphylactic events.
作者描述了一例荧光素血管造影术后发生过敏性休克的极其罕见的致命病例（文献报道中的第六例）。这是第一份通过实验室分析确诊对该染料发生过敏反应的报告。基于临床、实验室和免疫组化数据确诊了荧光素钠所致的致命性休克。测定了血清中的肥大细胞类胰蛋白酶，并进行了肺部免疫组化评估。类胰蛋白酶是人类肥大细胞的一种中性蛋白酶，是肥大细胞参与过敏反应的一个潜在重要指标。
