Araki K, Shinozaki T, Irie Y, Miyazawa Y
Department of Laboratory Medicine, Teikyo University School of Medicine.
Kansenshogaku Zasshi. 1999 Apr;73(4):305-10. doi: 10.11150/kansenshogakuzasshi1970.73.305.
It was investigated that Bifidobacterium breve YIT4064 (B. breve YIT4064), Which had augmented IgA production and prevented rotavirus-induced diarrhea in mice, prevented rotavirus infection in infants. The effect of B. breve YIT4064 was evaluated in ten infants from an infants home who received 50 mg of the bacterium every day for 28 days (the B. breve group). Nine infants did not receive this (the control group). Though rotavirus shedding in the control group was detected from 2 (a total of 5 stool samples) of 9 infants (a total of 112 stool samples), it was not detected in any infants (a total of 133 stool samples) in the B. breve group during the administration period. From day 8 to day 14 of the test, rotavirus shedding was detected from 4 of 32 stool samples in the control group, but was not detected at all from 38 stool samples in the B. breve group. The frequency of rotavirus shedding in the B. breve group was significantly lower than that in the control group. Further, the frequency in appearances of anti-IgA in stool samples in the B. breve group showed a tendency to increase in comparison with the control group from day 8 to 14 of the test. The oral administration of B. breve YIT4064 significantly decreased rotavirus shedding in stool samples and prevented rotavirus infection.
研究发现，短双歧杆菌YIT4064（B. breve YIT4064）可增强小鼠的IgA产生并预防轮状病毒引起的腹泻，它也能预防婴儿的轮状病毒感染。对一家婴儿院的10名婴儿进行了B. breve YIT4064效果评估，这些婴儿每天接受50毫克该细菌，持续28天（B. breve组）。9名婴儿未接受此处理（对照组）。尽管在对照组9名婴儿（共112份粪便样本）中的2名婴儿（共5份粪便样本）检测到轮状病毒排出，但在B. breve组的任何婴儿（共133份粪便样本）给药期间均未检测到。在试验的第8天至第14天，对照组32份粪便样本中的4份检测到轮状病毒排出，但B. breve组的38份粪便样本中完全未检测到。B. breve组轮状病毒排出频率显著低于对照组。此外，在试验的第8天至第14天，B. breve组粪便样本中抗IgA出现的频率与对照组相比有增加的趋势。口服B. breve YIT4064可显著降低粪便样本中轮状病毒的排出并预防轮状病毒感染。
